Therapeutic applications of RNAi : methods and protocols / edited by John F. Reidhaar-Olson, Cristina M. Rondinone. — Dordrecht ;London : Humana, c2009. – (58.17/M592/v.555)

Contents

    Contents
    
    Preface
    Contributors
    1 Development and Application of a Dual-Purpose Nanoparticle Platform for Delivery and Imaging of siRNA in Tumors
    2 Targeted Gene Silencing into Solid Tumors with Electrically Mediated siRNA Delivery
    3 Liposomal siRNA for Ovarian Cancer 29
    4 Therapeutic Applications of RNAi for Silencing Virus Replication 43
    5 RNAi in the Malaria Vector， Anophelesgambiae
    6 RNAi Using a Chitosan/siRNA Nanoparticle System: In Vitro and In Vivo Applications 77
    7 Lentiviral and Adeno-Associated Vector-Based Therapy for Motor Neuron Disease Through RNAi 87
    8 Studying Autoimmunity by In Vivo RNA Interference 109
    9 Transcriptional Gene Silencing Using Small RNAs 119
    10 Alternative Splicing as a Therapeutic Target for Human Diseases 127
    Index 145