Regulatory networks in stem cells / edited by Vinagolu K. Rajasekhar, Mohan C. Vemuri. — New York : Humana, c2009. – (58.155/R344)

Contents

    Contents
    
    Part I Molecular Regulation in Stem Cells
    The Molecular Basis of Embryonic Stem Cell Self-Renewal
    Asymmetric Behavior in Stem Cells
    Determinants of Pluripotency in Mouse and Human Embryonic Stem Cells 27
    Maintenance of Embryonic Stem Cell Pluripotency by Nanog-Mediated Dedifferentiation of Committed Mesoderm Progenitors 37
    Human Embryonic Stem Cells and Germ Cell Development 55
    Genomic Stability in Stem Cells
    Genetic Manipulation of Human Embryonic Stem Cells 75
    Transcriptional Networks Regulating Embryonic Stem Cell Fate Decisions 87
    Use of Zebrafish to Dissect Gene Programs Regulating Hematopoietic Stem Cells
    HOXB4 in Hematopoietic Stem Cell Regulation
    Telomere and Telomerase for the Regulation of Stem Cells 123
    The Role of Mitochondria in Stem Cell Biology 135
    Part II Regulation by Stem Cell Niches
    Stem Cells and Stem Cell Niches in Tissue Homeostasis: Lessons from the Expanding Stem Cell Populations of Drosophila 147
    Extrinsic and Intrinsic Control of Germline Stem Cell Regulation in the Drosophila Ovary 155
    The Niche Regulation of Hematopoietic Stem Cells 165
    Environmental Signals Regulating Mesenchymal Progenitor Cell Growth and Differentiation 175
    Microenvironmentai Regulation of Adult Mesenchymai Stem Cells 185
    Stem Cells， Hypoxia and Hypoxia-Inducible Factors 211
    Part III Epigenetic Mechanisms in Stem Cells
    Stem Cell Epigenetics
    Epigenetic Signature of Embryonal Stem Cells: A DNA Methylation Perspective 247
    Epigenetic Basis for Differentiation Plasticity in Stem Cells
    Role of DNA Methylation and Epigenetics in Stem Cells
    DNA Methylation and the Epigenetic Program in Stem Cells 277
    Polycomb Group Protein Homeostasis in Stem Cell Identity - A Hypothetical Appraisal
    Part IV Signaling and Regulation in Select Stem Cell Types
    Signaling Pathways in Embryonic Stem Cells
    Regulation of Stem Cell Systems by PI3K/Akt Signaling 309
    Endothelial Ontogeny During Embryogenesis: Role of Cytokine Signaling Pathways 319
    Signaling Networks in Mesenchymal Stem Cells 329
    Single-Cell Approaches to Dissect Cellular Signaling Networks 337
    Hematopoietic Stem Cells
    Renal Stem Cells and Kidney Regeneration
    The Endometrium: A Novel Source of Adult Stem/Progenitor Cells
    Epithelial Stem Cells and the Development of the Thymus， Parathyroid， and Skin
    Hepatic Stem Cells and Liver Development
    Part V Disease Paradigms and Stem Cell Therapeutics
    The Idea and Evidence for the Tumor Stemness Switch
    The Role of the Tumor Suppressor Fhit in Cancer-Initiating Cells
    History of Cancer Stem Cells
    Immune Responses to Stem Cells and Cancer Stem Cells
    Leukemic Stem Cells: New Therapeutic Targets?
    Solid Tumor Stem Cells - Implications for Cancer Therapy 527
    Therapeutic Approaches to Target Cancer Stem Cells
    Preclinical Evidence for Cellular Therapy as a Treatment for Neurological Disease
    Improving Memory with Stem Cell Transplantation 575
    Index 585