Gene therapy of cancer : methods and protocols / edited by Wolfgang Walther and Ulrike S. Stein. — 2nd ed. — [New York] : Humana Press, c2009. – (58.17/M592/v.542)

Contents

    CONTENTS
    
    Preface
    Contributors
    SECTION I: EXPERIMENTAL APPROACHES IN CANCER THERAPY
    SUBSECTION A: INTRODUCTION
    1 The Development of Gene Therapy: From Monogenic Recessive Disorders to Complex Diseases Such as Cancer
    SUBSECTION B: VECTOROLOGY FOR CANCER GENE THERAPY
    2 Designing Adenoviral Vectors for Tumor-Specific Targeting
    3 Analysis of HSV Oncolytic Virotherapy in Organotypic Cultures
    4 Use of Minicircle Plasmids for Gene Therapy
    5 Transposable Elements as Plasmid-Based Vectors for Long-Term Gene Transfer into Tumors 105
    6 Designing Plasmid Vectors
    7 Development of Bacterial Vectors for Tumor-Targeted Gene Therapy
    SUBSECTION C: NONVlRAL TRANSFER TECHNOLOGIES IN CANCER GENE THERAPY
    8 Electroporative Gene Transfer
    9 Gene Gun Delivery Systems for Cancer Vaccine Approaches
    10 Ultrasound-Mediated Gene Transfection
    11 Nonviral Jet-Injection Technology for Intratumoral In Vivo Gene Transfer of Naked DNA 195
    SUBSECTION D: EXPERIMENTAL STUDIES IN CANCER GENE THERAPY
    12 Methods for Constructing and Evaluating Antitumor DNA Vaccines 211
    13 Immunity of Lentiviral Vector-Modified Dendritic Cells
    14 Saporin Suicide Gene Therapy
    15 Using In Vivo Biopanning for the Development of Radiation-Guided Drug Delivery Systems
    16 Chemosensitization of Tumor Cells: Inactivation of Nuclear Factor-Kappa B Associated with Chemosensitivity in Melanoma Cells After Combination Treatment with E2F-1 and Doxorubicin
    17 Induction of Tumor Cell Apoptods by TRAIL Gene Therapy 315
    18 Silencing Epidermal Growth Factor Receptor by RNA Interference in Glioma 335
    19 Delivery of Phosphorodiamidate Morpholino Antisense Oligomers in Cancer Cells
    20 Use of RNA Aptamers for the Modulation of Cancer Cell Signaling 363
    21 G-Rich Oligonucleotides for Cancer Treatment
    SECTION II: CLINICAL APPROACHES IN CANCER GENE THERAPY
    SUBSECTION A: REQUIREMENTS FOR CLINICAL GENE THERAPY TRIALS
    22 Regulatory Aspects for Translating Gene Therapy Research into the Clinic
    23 Ethics of Cancer Gene Transfer Clinical Research
    24 Virus Production for Clinical Gene Therapy
    25 Production of Plasmid DNA as Pharmaceutical
    SUBSECTION B: CLINICAL PROTOCOLS IN CANCER GENE THERAPY
    26 Gene Immunotherapy for Non-Small Cell Lung Cancer
    27 Gene Therapy for Antitumor Vaccination 515
    28 HSV-tk/IL-2 Gene Therapy for Glioblastoma Multiforme 529
    29 Construction and Characterization of an Oncolytic HSV Vector Containing a Fusogenic Glycoprotein and Prodrug Activation for Enhanced Local Tumor Control 551
    30 Newcastle Disease Virus: A Promising Vector for Viral Therapy， Immune Therapy， and Gene Therapy of Cancer 565
    31 Oncolytic Viral Therapy Using Reovirus 607
    32 Design and Testing of Novel Oncolytic Vaccinia Strains 635
    33 Tumor-Targeted Salmonella typhimurium Overexpressing Cytosine Deaminase: A Novel， Tumor-Selective Therapy 649
    34 Chemoprotection by Transfer of Resistance Genes
    35 Phase I Clinical Trial of Locoregional Administration of the Oncolytic Adenovirus ONYX-015 in Combination with Mitomycin-C， Doxorubicin， and Cisplatin Chemotherapy in Patients with Advanced Sarcomas 705
    Index