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新书资源(2009年7月)

Leukemia : methods and protocols / edited by Chi Wai Eric So. — Totowa, N.J. : Humana, 2009. – (58.17/M592/v.538)

Contents

    Contents
    
    1 An Overview: From Discovery of Candidate Mutations to Disease Modeling and Transformation Mechanisms of Acute Leukemia
    2 Backtracking of Leukemic Clones to Birth
    3 Fluorescence In Situ Hybridization (FISH) as a Tool for the Detection of Significant Chromosomal Abnormalities in Childhood Leukaemia 29
    4 Specialized Fluorescence In Situ Hybridization (FISH) Techniques for Leukaemia Research
    5 LDI-PCR: Identification of Known and Unknown Gene Fusions of the Human MLL Gene
    6 Panhandle PCR Approaches to Cloning MLL Genomic Breakpoint Junctions and Fusion Transcript Sequences
    7 MRD Detection in Acute Lymphoblastic Leukemia Patients Using Ig/TCR Gene Rearrangements as Targets for Real-Time Quantitative PCR
    8 Array-Based Comparativc Genomic Hybridization as a Tool for Analyzing the Leukemia Genome
    9 Application of SNP Genotype Arrays to Determine Somatic Changes in Cancer
    10 Retroviral/Lentiviral Transduction and Transformation Assay
    11 Gene Expression Profiling of Leukemia Stem Cells 231
    12 Humanized Model to Study Leukemic Stem Cells 247
    13 Model Systems for Examining Effects of Leukemia Associated Oncogenes in Primary Human CD34+ Cells via Retroviral Transduction
    14 Ex Vivo Assays to Study Self-Renewal and Long-Term Expansion of Genetically Modified Primary Human Acute Myeloid Leukemia Stem Cells
    15 Identification and Characterization of Hematopoietic Stem and Progenitor Cell Populations in Mouse Bone Marrow by Flow Cytometry 301
    16 In Vitro Differentiation of Embryonic Stem Cells as a Model of Early Hematopoietic Development 317
    17 Analysis of the Mouse Placenta as a Hematopoietic Stem Cell Niche
    18 Identification of Protein Interaction Partners by the Yeast Two-Hybrid System 347
    19 Complete Array of HOX Gene Expression by RQ-PCR 369
    20 Genome-Wide Determination of DNA Methylation by HpaII Tiny Fragment Enrichment by Ligation-Mediated PCR (HELP) for the Study of Acute Leukemias 395
    21 Chromatin Immunoprecipitation (CHIP) for Analysis of Histone Modifications and Chromatin-Associated Proteins 409
    Index