Peptide-based drug design / edited by Laszlo Otvos. — Totowa, N.J. : Humana Press, c2008. – (58.17/M592/v.494)

Contents

    Contents
    
    Preface
    Contributors
    1. Peptide-Based Drug
    Design: Here and Now
    2. Strategies for the Discovery， Isolation， and Characterization of Natural Bioactive Peptides from the Immune System of Invertebrates
    3. Sequence Analysis of Antimicrobial Peptides by Tandem Mass Spectrometry 31
    4. The Spot Technique: Synthesis and Screening of Peptide Macroarrays on Cellulose Membranes 47
    5. Analysis of Aβ Interactions Using ProteinChip Technology 71
    6. NMR in Peptide Drug Development 87
    7. Molecular Dynamics Simulations of Peptides 115
    8. Short Linear Cationic Antimicrobial Peptides: Screening， Optimizing， and Prediction 127
    9. Investigating the Mode of Action of Proline-Rich Antimicrobial Peptides Using a Genetic Approach: A Tool to Identify New Bacterial Targets Amenable to the Design of Novel Antibiotics 161
    10. Serum Stability of Peptides
    11. Preparation of Glycosylated Amino Acids Suitable for Fmoc Solid-Phase Assembly 187
    12. Synthesis of O-Phosphopeptides on Solid Phase 209
    13. Peptidomimetics: Fmoc Solid-Phase Pseudopeptide Synthesis 223
    14. Predrag Cudic and Maciej Stawikowski Synthesis of Toll-Like Receptor-2 Targeting Lipopeptides as Self-Adjuvanting Vaccines 247
    15. Synthesis of a Multivalent， Multiepitope Vaccine Construct 263
    16. Cysteine-Containing Fusion Tag for Site-Specific Conjugation of Therapeutic and Imaging Agents to Targeting Proteins 275
    Index 295