Growth factors and psychiatric disorders — Chichester : Wiley, c2008. – (64.19/G884)

Contents

    Contents
    
    Symposium on Growth factors and psychiatric disorders， held at the Novartis Foundation， London， 20-22 March 2007
    Editors: Derek J. Chadwick (Organizer) and Jamie Goode
    This symposium is based on a proposal made by Moses Chao
    Chair's introduction 1
    Phenomenology， aetiology and treatment of schizophrenia 4
    Discussion 17
    Genetic variants in major depression 23
    Discussion 33
    Neurotrophins in depression and antidepressant effects 43
    Discussion 53
    Genetics of bipolar disorder: focus on BDNF Va166Met polymorphism 60
    Discussion 72
    Mechanisms of neuregulin action 74
    Discussion 84
    General discussion I 87
    The fibroblast growth factor family and mood disorders 94
    Discussion 97
    Trajectories of anatomic brain development as a phenotype 101
    Discussion 112
    Cell biology of BDNF and its relevance to schizophrenia 119
    Discussion 129
    Functions and mechanisms of BDNF mRNA trafficking 136
    Discussion 147
    Hippocampal neurogenesis and depression 152
    Discussion 160
    Neuregulins and neuronal plasticity: possible relevance in schizophrenia 165
    Discussion 177
    Impact of genetic variant BDNF (Va166Met) on brain structure and function 180
    Discussion 188
    General discussion II 193
    Growth and schizophrenia: aetiology， epidemiology and epigenetics 196
    Discussion 203
    What can we learn from the disrupted in schizophrenia 1 interactome: lessons for target identifi-cation and disease biology? 208
    Discussion 216
    Neurotrophins and cytokines in neuronal plasticity 222
    Discussion 233
    Closing remarks 238
    Index of contributors 241
    Subject index 243