The biology of extracellular molecular chaperones / [editors, Derek J. Chadwick and Jamie Goode]. — Chichester : Wiley, c2008. – (58.178083/B615)

Contents

    Contents
    
    Symposium on The biology of extracellular molecular chaperones， held at the Novartis Foundation， London， 5-7 June 2007
    Editors: Derek J. Chadwick (Organizer) and Jamie Goode
    This symposium is based on a proposal made by Brian Henderson， R. John Ellis and A. Graham Pock@
    Chair's introduction 1
    1962-2007: a cell stress odyssey 3
     Discussion 15
    The chaperone function meanings and myths 23
     Discussion 36
    Systems biology of molecular chaperone networks 45
     Discussion 54
    Unusual cellular disposition of the mitochondrial molecular chaperones Hsp60， Hsp70 and Hspl0 59
     Discussion 69
    Cell surface molecular chaperones as endogenous modulators of the innate immune response 74
     Discussion 79
    Cell stress proteins in extracellular fluids: friend or foe? 86
     Discussion 96
    HSP60 speaks to the immune system in many voices 101
     Discussion 111
    Cell stress proteins: novel immunotherapeutics 115
     Discussion 131
    General discussion 137
    Cell stress proteins as modulators of bacteria-host interactions 141
     Discussion 154
    Chaperonin 60 and macrophage activation 160
     Discussion 169
    Hsp70: a chaperokine 173
     Discussion 179
    Extracellular functions of thioredoxin 184
     Discussion 192
    HSP27: an anti-inflammatory and immunomodulatory stress protein acting to dampen immune function 196
     Discussion 208
    BiP， an anti-inflammatory ER protein， is a potential new therapy for the treatment of rheumatoid arthritis 212
     Discussion 216
    Final discussion 221
    Index of contributors 225
    Subject index 227