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Advances in immunology. v. 100 / edited by Emil R. Unanue, Hugh O. McDevitt. — Amsterdam : Elsevier, c2008. – (58.691/A244/v.100) |
Contents
Contents
1. Autoimmune Diabetes MellitusmMuch Progress， but Many Challenges
1. Models of Type 1 DM
2. The Histocompatibility Molecules of the Autoimmune Diabetic
3. The Diabetic Antigens and the Diabetogenic T Cells
4. The Genetics of Type 1 Diabetes
5. Development of New Therapies in the NOD Model Which Show Promise in Studies in Patients
6. Effects of Administration of Glutamic Acid Decarboxylase 65 (GAD 65) to Patients with Recent-Onset T1D
7. The Prospect for Trials to Prevent TIDM in Susceptible Human Populations
References
2. CD3 Antibodies as Unique Tools to Restore Self-Tolerance in Established Autoimmunity: Their Mode of Action and Clinical Application in Type 1 Diabetes
1. Introduction
2. CD3 Antibodies as Promising Tolerance-Promoting Tools: The Proof of Concept in T1D
3. The Clinical Results in T1D: More than 25 Years of Effort
4. Why is The Effect of CD3-Antibody Based Therapy Antigen Specific and Long Lasting?
5. Building on the Present Clinical Experience to Improve CD3 Antibody Therapy in –lid
6. Conclusions
References
3. GAD65 Autoimmunitym—Clinical Studies
1. Introduction
2. GAD65 Autoimmunity in T1D
3. Pathogenesis of GAD65 Autoimmunity
4. Preclinical GAD65 Studies
5. Phase I GAD65 Clinical Studies
6. Phase II GAD65 Clinical Studies
7. Ongoing and Future Clinical Studies
8. Concluding Remarks Acknowledgments
References
4. CD8-1- T Cells in Type 1 Diabetes
1. Introduction
2. MHC Class I and T]D
3. Autoreactive CD8+ T Cells in T]D
4. Antigens for Diabetogenic CD8-1- T Cells in Humans
5. The Relative Contribution of the 13-Cell-Specific CD8+Response to T1D
6. Development and Activation of Diabetogenic CD8-1- T Cells
7. Recruitment of Diabetogenic CD8-t- T Cells to Islets
8. Mechanisms of 13-Cell Cytotoxicity in -FID
9. Induction of Immunologic Tolerance in Diabetogenic CD8+ T Cells
10. Concluding Remarks Acknowledgments
References
5. Dysregulation of T Cell Peripheral Tolerance in Type 1 Diabetes
1. Introduction
2. The Autoimmune Process of T1D
3. Dysregulation of Central T Cell Tolerance in T1D
4. Dysregulation of Peripheral T Cell Tolerance in liD
5. Summary Acknowledgments
References
6. Gene-Gene Interactions in the NOD Mouse Model of Type 1 Diabetes 151
1. Type 1 Diabetes is a Multigenic Disease
2. Insights into a Multigenic Disease: The NOD Mouse
3. Defining the Function of Alleles Altering the Frequency of T1D
4. Functional Studies with NOD Congenic Mice: The Combination of Protective Alleles at Idd3 and Idd5 Prevent Diabetes and Insulitis
5. Review of Idd3
6. Review of Idd5
7. Genetic Complexity of IddS: Genetic Masking and the Discovery of IddS.3 and IddS.4
8. Combining Protective Alleles at 112/Idd3 with those from the Idd5 Subregions
9. Conclusion
Acknowledgements
References
