Essential concepts in toxicogenomics / edited by Donna L. Mendrick and William B. Mattes. — Totow, N.J. : Humana Press, c2008. – (58.17/M592/v.460)

Contents

    Contents
    
    Preface v
    Contributors ix
    Color Plates xi
    1 Toxicogenomics and Classic Toxicology: How to Improve Prediction and Mechanistic Understanding of Human Toxicity
    2 Use of Traditional End Points and Gene Dysregulation to Understand Mechanisms of Toxicity: Toxicogenomics in Mechanistic Toxicology
    3 Quality Control of Microarray Assays for Toxicogenomic and In Vitro Diagnostic Applications
    4 Role of Statistics in Toxicogenomics
    5 Predictive Toxicogenomics in Preclinical Discovery
    6 In Vivo Predictive Toxicogenomics
    7 Bioinformatics: Databasing and Gene Annotation
    8 Microarray Probe Mapping and Annotation in Cross-Species Comparative Toxicogenomics
    9 Toxicogenomics in Biomarker Discovery
    10 From Pharmacogenomics to Translational Biomarkers
    11 Public Consortium Efforts in Toxicogenomics
    12 Applications of Toxicogenomics to Nonclinical Drug Development: Regulatory Science Considerations