Advances in genetics. v. 62 / edited by Jeffrey C. Hall ... [et al]. — Amsterdam : Elsevier, c2008. – (58.14/A244/v.62)

Contents

        Contents
    
    Contributors
    1 Common Genetic Variation and Human Disease
    I. Introduction 2
    II. Variation in the Human Genome 3
    III. Utilization of Genetic Variation in Gene Mapping Studies 7
    IV. Mapping Complex Disease Genes Using Association 11
    V. Genome-wide Association Studies 17
    VI. Study Design and Data Analysis 19
    VII. Significance for Public Health 22
    VIII. Concluding Remarks 23
    2 Genetics of the Framingham Heart Study Population 33
    I. Introduction 35
    II. The Study Population 36
    III. Phenotypic and Genetic Architecture of Complex Traits 41
    IV. Linkage and Association Studies 49
    V. Genotype-Environment Interactions 55
    VI. Ethical Issues 56
    VII. Prospects and Conclusions 56
    3 Neurogenetics of Courtship and Mating in Drosophila
    I. Introduction 70
    II. Mutations and Genes Affecting Sensory Functions That Control Courtship 72
    III. Neurogenetics of the CNS's Control of Sex-Specific Behaviors 94
    IV. Genetic Manipulations of Experience-Dependent Reproductive Behavior 110
    V. fruitless: A Crucial Single-Gene Regulator of Male-Specific Behavior and Sexual Differentiation of the Nervous System 118
    VI. Neurogenetic Relationships Between the Regulation of Reproduction and Rhythms 155
    VII. Conclusions and Prospects 160
    4 NMD: Multitasking Between mRNA Surveillance and Modulation of Gene Expression
    I. Introduction 186
    II. Mechanism and Actors 188
    III. Targets of NMD 212
    IV. Disobedient NMD Targets 217
    V. Good Cop， Bad Cop: Medical Importance of NMD 219
    VI. Moonlighting NMD Proteins: Moonlighting Pathway? 223
    VII. Conclusions 231
    References 232