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Molecular biology of the gene / James D. Waston ... [et al]. — 5th ed. — San Francisco : Pearson/Benjamin Cummings ; Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboatory Press, c2004. – (58.1573/W339/5th ed.)

Contents

    Contents
    
    PART 1 CHEMISTRY AND GENETICS 1
    1 The Mendelian View of the World 5
    2 Nucleic Acids Convey Genetic Information 19
    3 The Importance of Weak Chemical Interactions 41
    4 The Importance of High-Energy Bonds 55
    5 Weak and Strong Bonds Determine Macromolecular Structure 69
    PART 2 MAINTENANCE OF THE GENOME 93
    6 The Structures of DNA and RNA 97
    7 Chromosomes, Chromatin, and the Nucleosome 129
    8 The Replication of DNA 181
    9 The Mutability and Repair of DNA 235
    10 Homologous Recombination at the Molecular Level 259
    11 Site-Specific Recombination and Transposition of DNA 293
    PART 3 EXPRESSION OF THE GENOME 343
    12 Mechanisms of Transcription 347
    13 RNA Splicing 379
    14 Translation 411
    15 The Genetic Code 461
    PART 4 REGULATION 479
    16 Gene Regulation in Prokaryotes 483
    17 Gene Regulation in Eukaryotes 529
    18 Gene Regulation during Development 575
    19 Comparative Genomics and the Evolution of Diversity 613
    PART 5 METHODS 643
    20 Techniques of Molecular Biology 647
    21 Model Organisms 681
    Index 713