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Advances in immunology. v. 98 / edited by Frederick W. Alt. — Amsterdam : Elsevier, c2008. – (58.691/A244/v.98) |
Contents
Contents
1. Immune Regulation by B Cells and Antibodies: A View Towards the Clinic
1. Introduction
2. Prevention of Rhesus D Hemolytic Disease of the Newborn with Anti-D Antibodies
3. Antibody-Based Treatment of Immune Thrombocytopenia Purpura
4. Immune Regulating Functions of Naive and Activated B Ceils
Acknowledgments
References
2. Cumulative Environmental Changes， Skewed Antigen Exposure， and the Increase of Allergy
1. Introduction
2. Antigen Exposure during Times When the Immune System Evolved
3. Did Allergy Play a Role in the Evolution of the Human Immune System?
4. Environmental and Lifestyle Changes Alter Humans' Antigen Exposure
5. Significant Changes in Lifestyle and Environment since H. sapiens Stated to Use Fire
6. Significant Lifestyle and Environmental Changes since the Industrial Revolution
7. The Increase in Proportions of Environmental Antigens of Limited Varieties
8. Prevalence of Allergy is Related to Changes in Antigen Exposure
9. The Hygiene Hypothesis and Its Immunological Basis
10. Key Factors Affecting the IgE-Mediated Pathway in Allergic Responses
11. Total IgE vs. Allergen-Specific IgE
12. Allergenic Substances Become Dominant Mucosal IgE Stimulators
13. Molecular Mechanisms Delineating the Effects of the Skewed Antigen Exposure on the Sensitization of the IgE Pathway
14. Concluding Remarks
Acknowledgments
References
3. New Insights on Mast Cell Activation via the High Affinity Receptor for IgE
1. Introduction
2. A General Outline of FcεRI Signaling
3. Recent Advances in FcεRI Proximal Signaling
4. Regulation of Calcium Mobilization in Mast Cells
5. Sphingosine-l-phosphate: A Co-stimulatory Signal in FcεRI -mediated Mast Cell Activation
6. The Role of Genetics in Mast Cell Responsiveness
7. Summary and Perspectives
References
4. B Cells and Autoantibodies in the Pathogenesis of Multiple Sclerosis and Related Inflammatory Demyelinating Diseases
1. MS and Related Inflammatory Demyelinating CNS Diseases
2. Therapeutic Depletion of B Cells in MS with Rituximab
3. Which B Cell Functions are Critical in the Pathogenesis of MS?
4. Conclusions and Future Directions
References
5. Human B Cell Subsets
1. Introduction
2. Human B Cell Subsets: Current Separation Schemes
3. Transitions in Peripheral B cell Development
4. Monoclonal Antibodies from Human B Cell Subsets: Insights into Autoreactivity and Function
5. Vaccine-induced Plasma Cells and Recombinant Antibodies: A Rapid Source of Fully Human Mabs
6. Autoimmune Disease and Human B Cell Subsets
7. Summary
References
Index
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