Advances in virus research. v. 71 / edited by Karl Maramorosch, Aaron J. Shatkin, Frederick A. Murphy. — New York : Academic Press, 2008. – (58.679/A244/v.71) |
Contents
Contents
1. The Pathogenesis of Poliomyelitis: What We Don't Know
I. Introduction
II. Sequential Steps in the Spread of Infection
III. Provocation Poliomyelitis
IV. PVR, Tropism, and the Localization of Lesions
V. Host Innate and Immune Response to Infection
VI. Immune Defenses and Viral Clearance: Mechanisms of Vaccine-Induced Protection
VII. Animal Models of Human Poliomyelitis
VIII. Virulence of Polioviruses
IX. How Does Poliovirus Persist?
X. Eradication
XI. Vaccine-Derived Polioviruses and the Eradication Endgame
XII. Reprise
Acknowledgments
References
2. Cutting the Gordian Knot-Development and Biological Relevance of Hepatitis C Virus Cell Culture Systems
I. Introduction
II. Genetic Heterogeneity of HCV--Genotypes, Subtypes, Isolates, and Quasispecies
III. The HCV Genome and Its Encoded Proteins
IV. Host Cell Factors Supporting the HCV Life Cycle
V. Consensus HCV cDNA Clones--Infectious in Transfected Chimpanzees
VI. The Replicon System--Autonomous HCV RNA Replication in Hepatoma Cell Lines
VII. Pseudo-Particles Expressing the HCV Envelope Proteins (HCVpp)--A System for the Study of Viral Entry and Neutralization
VIII. The JFHI Isolate--Generation of Cell Culture Derived HCV (HCVcc) in Full Viral Life Cycle Cell Culture Systems
IX. Perspectives for Further Development of HCV Cell Culture Systems
X. Conclusion--Implications of Novel Cell Culture Systems
Acknowledgments
References
3. Poxvirus Host Range Genes
I. Introduction
II. Orthopoxvirus Host Range Genes
III. Myxoma Virus Host Range Genes
IV. Molluscum Contagiosum: An Extreme Example of Host Range Restriction
V. Conclusions
Acknowledgments
References
4. Receptor Interactions, Tropism, and Mechanisms Involved in MorbiUivirus-lnduced Immunomodu|ation
I. Introduction
II. Leukopenia Associated with Morbillivirus Infections
III. Mechanisms and Consequences of T Cell Silencing in Morbillivirus Infections
IV. Receptors and Signaling Involved in Suppression of Cell Functions
V. Virus Interactions with DCs
VI. Conclusions and Perspectives
References
5. Lyssaviruses-Current Trends
I. introduction
II. Developments in Diagnostic and Surveillance Tools
III. Fundamental Aspects of Virus-Host Interactions
IV. Reverse Genetics--Methodology and Applications
V. Other Strategies for Rabies Vaccine Development
VI. The Challenge of Rabies Biologics for Passive Immunity
VII. Novel Applications of RABV
VIII. Concluding Remarks
References