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Advances in virus research. v. 71 / edited by Karl Maramorosch, Aaron J. Shatkin, Frederick A. Murphy. — New York : Academic Press, 2008. – (58.679/A244/v.71)

Contents

    Contents
    
    1. The Pathogenesis of Poliomyelitis: What We Don't Know
    I. Introduction
    II. Sequential Steps in the Spread of Infection
    III. Provocation Poliomyelitis
    IV. PVR, Tropism, and the Localization of Lesions
    V. Host Innate and Immune Response to Infection
    VI. Immune Defenses and Viral Clearance: Mechanisms of Vaccine-Induced Protection
    VII. Animal Models of Human Poliomyelitis
    VIII. Virulence of Polioviruses
    IX. How Does Poliovirus Persist?
    X. Eradication
    XI. Vaccine-Derived Polioviruses and the Eradication Endgame
    XII. Reprise
    Acknowledgments
    References
    2. Cutting the Gordian Knot-Development and Biological Relevance of Hepatitis C Virus Cell Culture Systems
    I. Introduction
    II. Genetic Heterogeneity of HCV--Genotypes, Subtypes, Isolates, and Quasispecies
    III. The HCV Genome and Its Encoded Proteins
    IV. Host Cell Factors Supporting the HCV Life Cycle
    V. Consensus HCV cDNA Clones--Infectious in Transfected Chimpanzees
    VI. The Replicon System--Autonomous HCV RNA Replication in Hepatoma Cell Lines
    VII. Pseudo-Particles Expressing the HCV Envelope Proteins (HCVpp)--A System for the Study of Viral Entry and Neutralization
    VIII. The JFHI Isolate--Generation of Cell Culture Derived HCV (HCVcc) in Full Viral Life Cycle Cell Culture Systems
    IX. Perspectives for Further Development of HCV Cell Culture Systems
    X. Conclusion--Implications of Novel Cell Culture Systems
    Acknowledgments
    References
    3. Poxvirus Host Range Genes
    I. Introduction
    II. Orthopoxvirus Host Range Genes
    III. Myxoma Virus Host Range Genes
    IV. Molluscum Contagiosum: An Extreme Example of Host Range Restriction
    V. Conclusions
    Acknowledgments
    References
    4. Receptor Interactions, Tropism, and Mechanisms Involved in MorbiUivirus-lnduced Immunomodu|ation
    I. Introduction
    II. Leukopenia Associated with Morbillivirus Infections
    III. Mechanisms and Consequences of T Cell Silencing in Morbillivirus Infections
    IV. Receptors and Signaling Involved in Suppression of Cell Functions
    V. Virus Interactions with DCs
    VI. Conclusions and Perspectives
    References
    5. Lyssaviruses-Current Trends
    I. introduction
    II. Developments in Diagnostic and Surveillance Tools
    III. Fundamental Aspects of Virus-Host Interactions
    IV. Reverse Genetics--Methodology and Applications
    V. Other Strategies for Rabies Vaccine Development
    VI. The Challenge of Rabies Biologics for Passive Immunity
    VII. Novel Applications of RABV
    VIII. Concluding Remarks
    References