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The RNA world : the nature of modern RNA suggests a prebiotic RNA world / edited by Raymond F. Gesteland, Thomas R. Cech, John F. Atkins. — 3rd ed. — Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, c2006. (58.174251/R486w/3rd ed.) |
Contents
Contents
Preface
Foreword to the First Edition
Prologue to the First Edition
THE ORIGINS OF RNA AND RNAATTHE ORIGIN
1 Setting the Stage: The History， Chemistry， and Geobiology behind RIGA， 1
2 Progress toward Understanding the Origin of the RNA World， 23
3 Protocells: Genetic Polymers Inside Membrane Vesicles， 57
BUILDING A FUNCTIONAL RNA
4 Riboswitches and the RNA World， 89
5 Catalytic Strategies of Self-Cleaving Ribozymes Relics of an RNA World?， 109
6 How the Group I Intron Works: A Case Study of RNA Structure and Function， 133
EXITING THE ANCIENT RNA WORLD--SYNTHETASES AND RIBOSOMES
7 RNA， Lipids， and Membranes， 207
8 Aminoacyl tRNA Synthetases: From the RNA World to the Theater of Proteins， 227
9 The Roles of RNA in the Synthesis of Protein， 257
10 Evolution of Ribosomes and Translation from an RNA World， 287
RICHNESS OF RNA ROLES IN A MODERN RNA WORLD
11 The RNP World， 309
12 The Ever-Growing World of Small Nuclear Ribonucleoproteins， 327
13 Spliceosome Structure and Function， 369
14 Uridine Insertion/Deletion RNA Editing as a Paradigm for Site-specific Modifications of RNA Molecules， 401
15 Telomerase RNA， 419
16 The Shapely mRNA: Knotting Ventured， Knotting Gained， 437
RNA CONTINUES TO TRIUMPH OVER DNA
17 Group II Introns: Ribozymes That Splice RNA and Invade DNA， 469
18 SINEs and LINEs: Troublemakers， Saboteurs， Benefactors， Ancestors， 507
19 The Biology of Short RNAs， 535
20 Versatile Roles of Small RNA Regulators in Bacteria， 567
21 Large Noncoding RNAs in Mammalian Gene Dosage Regulation， 595
EMERGING TOOLS
22 Predicting RNA Secondary Structure， 631
23 A Modular， : and Hierarchical Approach for All-Atom RNA modeling， 659
24 Automated In Vitro Selection and Microarray Applications for Functional RNA Sequences， 683
25 RNA Folding， Unfolding， and Dynamics， One Molecule at a Time， 721
Appendix， 747
Index， 753
