The molecular basis of cancer / [edited by] John Mendelsohn ... [et al.]. — 3rd ed. — Philadelphia, PA : Saunders/Elsevier, c2008. – (64.82/M537/3rd ed.)

Contents

    Contents
    
    Dedication
    List of Contributing Authors
    Preface
    I CARCINOGENESIS AND CANCER GENETICS
    1 Cancer: A Genetic Disorder
    2 Oncogenes and Signal Transduction
    3 Tumor Suppressor Genes
    4 DNA Repair Pathways and Human Cancer
    5 Epigeneticsand Cancer
    6 Infectious Agents and Cancer
    7 Environmental Carcinogenesis
    8 Animal Models: Flies， Fish， and Yeast
    9 Genetic Mouse Models of Cancer
    II CANCER BIOLOGY
    10 Cancer Stem Cells
    11 SignaI Transduction by Growth Factor Receptors
    12 Cell Growth
    13 Regulation of the Cell Cycle
    14 Metabolism of Cell Growth and Proliferation
    15 Apoptosis， Autophagy， and Necrosis
    16 Cellular Senescence
    17 The tumor microenvironment in cancer progression
    18 Tumor Angiogenesis
    19 Invasion and Metastasis
    III MOLECULAR PATHOLOGY AND DIAGNOSTICS
    20 Cancer Genomics
    21 Transcriptome Analysis
    22 Mass Spectrometry in Cancer Biology 293
    23 Imaging and Cancer
    24 Bioinformatics
    25 Early Detection of Cancer: Molecular Screening
    IV MOLECULAR PATHOGENESIS OF SPECIFIC MALIGNANCIES
    26 Lymphoma/Myeloma
    27 Molecular Genetics of ALL
    28 Biology of Chronic and Acute Myeloid Leukemia
    29 Molecular Biology of Childhood Neoplasms
    30 Molecular Basis of Lung Cancer
    31 Molecular Abnormalities in Colon and Rectal Cancer
    32 Breast Cancer
    33 Molecular Basis of Prostate Cancer
    34 Molecular Pathogenesis of Epithelial Ovarian Cancer
    35 Molecular Pathogenesis of Pancreatic Adenocarcinoma
    36 Molecular Biology of Melanoma
    37 Soft-Tissue Sarcomas
    38 Head and Neck Squamous Cell Carcinoma
    39 Primary Brain Tumors
    40 Epithelial Skin Cancer
    41 Endocrine Cancer
    42 Gastric and Gastroesophageal Adenocarcinoma
    V MOLECULAR BASIS OF CANCER THERAPY
    43 From Bench to Bedside with Targeted Therapies
    44 Screening Strategies for Targeted Therapeutics
    45 Animal Models to Predict Anticancer Efficacy
    46 Pharmacokinetics， Pharmacodynamics， and Pharmacogenetics
    47 Phase 1 Trials Today
    48 Cancer Therapeutics
    49 Natural and Acquired Resistance to Cancer Therapies
    50 Molecular Basis of Radiation Therapy 593
    51 Hematopoietic Growth Factors and Cytokines
    52 Interferons
    53 Cancer and the Cellular Immune Response
    54 Cancer-Specific Vaccines
    55 Monodonal Antibody Therapy of Cancer
    56 Gene Therapy and Oncolytic Viruses
    57 RNA as a Therapeutic Molecule
    58 Heat Shock Protein 90 and the Proteasome
    59 Cancer Chemoprevention
    Index