Whats wrong with my mouse? : behavioral phenotyping of transgenic and knockout mice / Jacqueline N. Crawley. — 2nd ed. — Hoboken, N.J. : Wiley-Interscience, c2007. – (59.59/C911/2nd ed.) |
Contents
Contents
Preface
Preface to the First Edition
Acknowledgments
Chapter 1 Designer Mice
Scope and sourcebooks
Chapter 2 Of Unicorns and Chimeras
How to generate a line of transgenic or knockout mouse for behavioral phenotyping
Chapter 3 General Health
Give your mouse a physical
Chapter 4 Motor Functions
Open field, holeboard, rotarod, balance, grip, circadian activity, circling, stereotypy, ataxic gait, seizures
Chapter 5 Sensory Abilities
Olfaction, vision, hearing, taste, touch, nociception
Chapter 6 Learning and Memory
Morris swim task, spatial mazes, cued and contextual conditioning, conditioned taste aversion, conditioned eyeblink, olfactory discrimination, social recognition, passive avoidance, schedule controlled operant tasks, motor learning, attention
Chapter 7 Feeding and Drinking
Daily consumption, restricted access, choice tests, microstructural analysis
Chapter 8 Reproductive Behaviors
Sexual and parental behaviors
Chapter 9 Social Behaviors
Social interaction, nesting, grooming, juvenile play, aggression
Chapter 10 Emotional Behaviors: Animal Models of Psychiatric Diseases 226
Mouse models of fear, anxiety, depression, schizophrenia
Chapter 11 Reward
Self-administration of addictive drugs, conditioned place preference
Chapter 12 Neurodevelopment and Neurodegeneration
Assaying behaviors in infant, juvenile, and aged mice
Chapter 13 Putting It All Together
Choice of tests, order of testing, number of mice, equipment, housing and testing environment
Chapter 14 The Next Generation
Conditional and inducible mutations, viral vector gene delivery, RNA silencing, quantitative trait loci analysis, DNA microarrays, chemical mutagenesis, gene therapy, ethical issues
References
Index