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新书资源(2008年8月)

Whats wrong with my mouse? : behavioral phenotyping of transgenic and knockout mice / Jacqueline N. Crawley. — 2nd ed. — Hoboken, N.J. : Wiley-Interscience, c2007. – (59.59/C911/2nd ed.)

Contents

    Contents
    
    Preface
    Preface to the First Edition
    Acknowledgments
    Chapter 1 Designer Mice
    Scope and sourcebooks
    Chapter 2 Of Unicorns and Chimeras
    How to generate a line of transgenic or knockout mouse for behavioral phenotyping
    Chapter 3 General Health
    Give your mouse a physical
    Chapter 4 Motor Functions
    Open field, holeboard, rotarod, balance, grip, circadian activity, circling, stereotypy, ataxic gait, seizures
    Chapter 5 Sensory Abilities
    Olfaction, vision, hearing, taste, touch, nociception
    Chapter 6 Learning and Memory
    Morris swim task, spatial mazes, cued and contextual conditioning, conditioned taste aversion, conditioned eyeblink, olfactory discrimination, social recognition, passive avoidance, schedule controlled operant tasks, motor learning, attention
    Chapter 7 Feeding and Drinking
    Daily consumption, restricted access, choice tests, microstructural analysis
    Chapter 8 Reproductive Behaviors
    Sexual and parental behaviors
    Chapter 9 Social Behaviors
    Social interaction, nesting, grooming, juvenile play, aggression
    Chapter 10 Emotional Behaviors: Animal Models of Psychiatric Diseases 226
    Mouse models of fear, anxiety, depression, schizophrenia
    Chapter 11 Reward
    Self-administration of addictive drugs, conditioned place preference
    Chapter 12 Neurodevelopment and Neurodegeneration
    Assaying behaviors in infant, juvenile, and aged mice
    Chapter 13 Putting It All Together
    Choice of tests, order of testing, number of mice, equipment, housing and testing environment
    Chapter 14 The Next Generation
    Conditional and inducible mutations, viral vector gene delivery, RNA silencing, quantitative trait loci analysis, DNA microarrays, chemical mutagenesis, gene therapy, ethical issues
    References
    Index