Genetic dissection of complex traits / edited by D.C. Rao, C. Charles Gu. — 2nd ed. — San Diego : Academic Press, c2008. – (58.14/A244/v.60)

Contents

        Contents
    
    Part I: Overview and Fundamentals 1
    1 An Overview of the Genetic Dissection of Complex Traits 3
    2 Familial Resemblance and Heritability 35
    3 Linkage and Association: Basic Concepts 51
    4 Definition of Phenotype 75
    5 Genotyping Platforms for Mass-Throughl Genotyping with SNPs， Including Human Genome-Wide Scans 107
    6 Genotyping Errors and Their Impact on Genetic Analysis 141
    Part II: Linkage and Association Analysis 153
    7 Model-Based Methods for Linkage Analysis 155
    8 Contemporary Model-Free Methods for Linkage Analysis 175
    9 DNA Sequence-Based Phenotypic Association Analysis 195
    10 Family-Based Methods for Linkage and Association Analysis 219
    11 Searching for Additional Disease Loci in a Genomic Region 253
    12 Methods for Handling Multiple Testing 293
    Part III: Special Topics 309
    13 Meta-Analysis Methods 311
    14 Haplotype-Association Analysis 335
    15 Characterization of LD Structures and the Utility of HapMap in Genetic Association Studies 407
    16 Associations Among Multiple Markers and Complex Disease: Models， Algorithms， and Applications
    17 Study Designs for Genome-Wide Association Studies 465
    18 Ethical， Legal， and Social Implications of Biobanks for Genetics Research 505
    Part IV: Promising Topics 545
    19 Admixture Mapping and the Role of Population Structure for Localizing Disease Genes 547
    20 Integrating Global Gene Expression Analysis and Genetics 571
    21 A Systems Biology Approach to Drug Discovery 603
    22 The Promise of Composite Likelihood Methods for Addressing Computationally Intensive Challenges 637
    23 Comparative Genomics for Detecting Human Disease Genes 655
    Part V: Outstanding Challenges 699
    24 From Genetics to Mechanism of Disease Liability 701
    25 Into the Post-HapMap Era 727