Target discovery and validation : reviews and protocols. v. 2, Emerging molecular targets and treatment options / edited by Mouldy Sioud. — Totowa, N.J. : Humana Press, c2007. – (58.17/M592/v.361) |
Contents
Contents
Preface
Contributors
Contents of Volume 1
1 Druggable Signaling Proteins
2 DNA Methylation and Histone Modifications in Patients With Cancer: Potential Prognostic and Therapeutic Targets
3 Wnt Signaling as a Therapeutic Target for Cancer
4 The NG2/HMP Proteoglycan as a Cancer Therapeutic Target
5 Heterotrimeric G Proteins and Disease
6 High-Mobility Group Box-1 Isoforms as Potential Therapeutic Targets in Sepsis
7 Antisense Oligonucleotides: Target Validation and Development of Systemically Delivered Therapeutic Nanoparticles
8 Nucleic Acid-Based Aptamers as Promising Therapeutics in Neoplastic Diseases
9 Guidelines for the Selection of Effective Short-Interfering RNA Sequences for Functional Genomics
10 Suppression of Apoptosis in the Liver by Systemic and Local Delivery of Small-Interfering RNA
11 Target Validation Using RNA Interference in Solid Tumors
12 Validation of Telomerase and Survivin as Anticancer Therapeutic Targets Using Ribozymes and Small-Interfering RNAs
13 Collagen-Induced Arthritis in Mice: A Major Role for Tumor Necrosis Factor-α
14 Novel Opportunities for Therapeutic Targeting in Systemic Autoimmune Diseases
15 Considerations for Target Validation and Industrial Approaches
16 Regulatory RNAs: Future Perspectives in Diagnosis, Prognosis, and Individualized Therapy
17 Treatment Options and Individualized Medicine
Index 341