Target discovery and validation : reviews and protocols. v. 1, Emerging strategies for targets and biomarker discovery / edited by Mouldy Sioud. — Totowa, N.J. : Humana Press, c2007. – (58.17/M592/v.360)

Contents

    Contents
    
    Preface
    Contributors
    Contents of Volume 2
    1 Main Approaches to Target Discovery and Validation
    2 Bioinformatics Approaches to Cancer Gene Discovery
    3 Analysis of Gene Networks for Drug Target Discovery and Validation
    4 Target Discovery and Validation in Pancreatic Cancer
    5 Molecular Classification of Breast Tumors: Toward Improved Diagnostics and Treatments
    6 Discovery of Differentially Expressed Genes: Technical Considerations
    7 Genome-Wide Screening by Using Small-Interfering RNA-Expression Libraries
    8 Hammerhead Ribozyme-Based Target Discovery
    9 Production of siRNA and cDNA-Transfected Cell Arrays on Noncoated Chambered Coverglass for High-Content Screening Microscopy in Living Cells
    10 Transgenic Animal Models in Biomedical Research
    11 Keratin Transgenic and Knockout Mice: Functional Analysis and Validation of Disease-Causing Mutations
    12 The HUVEC/Matrigel Assay: An In Vivo Assay of Human Angiogenesis Suitable for Drug Validation
    13 A Murine Model for Studying Hematopoiesis and Immunity in Heart Failure
    14 An Overview of the Immune System and Technical Advances in Tumor Antigen Discovery and Validation
    15 Potential Target Antigens for Immunotherapy Identified by Serological Expression Cloning (SEREX)
    16 Identification of Tumor Antigens by Using Proteomics
    17 Protein Arrays: A Versatile Toolbox for Target Identification and Monitoring of Patient Immune Responses
    Index 349