Mitochondria / Immo E. Scheffler. — 2nd ed. — Hoboken, N.J. : Wiley-Liss, c2008. – (58.1554/S318/2nd ed.)

Contents

    CONTENTS
    
    Preface
    Preface to First Edition
    1 History
    2 Evolutionary Origin of Mitochondria
    3 Structure and Morphology. Integration into the Cell
    3.1 Structure and Morphology， 19
    3.2 Integration into the Cell， 30
    3.3 The Dynamics of Mitochondrial Morphology， 37
    4 Biogenesis of Mitochondria
    4.1 The Mitochondrial Genome， 61
    4.2 Nuclear Genes Encoding Mitochondrial Proteins， 81
    4.3 Replication and Maintenance of Mitochondrial DNA， 96
    4.4 Transcription of Mitochondrial DNA-RNA Metabolism， 105
    4.5 Translation of Mitochondrial mRNAs， 126
    4.6 Protein Import into Mitochondria， 141
    4.7 Import of Transfer RNA into Mitochondria， 152
    4.8 Regulated Protein Degradation in Mitochondria， 153
    5 Mitochondrial Electron Transfer and Oxidative Phosphorylation 168
    5.1 Historical Introduction， 169
    5.2 The Electron Transport Chain， 173
    5.3 Electron Transport in Other Organisms， 224
    5.4 The Chemiosmotic Hypothesis， 228
    5.5 ATP Synthase (FIF0-ATPase)， 244
    5.6 Control of Respiration and Oxidative Phosphorylation， 259
    5.7 Reactive Oxygen Species， 272
    5.8 Nitric Oxide (NO)， 277
    5.9 The Role of Specific Lipids， 279
    6 Metabolic Pathways Inside Mitochondria 298
    6.1 Introduction， 299
    6.2 The Krebs Cycle， 299
    6.3 Fatty Acid Metabolism， 304
    6.4 The Urea Cycle， 309
    6.5 Biosynthesis of Heine， 309
    6.6 Cardiolipin and Lipid Biosynthesis/Metabolism， 314
    6.7 Biosynthesis of Ubiquinol (Coenzyme Q)， 319
    6.8 Biosynthesis of Fe-S Centers， 324
    6.9 Transport of Small Solutes into and out of Mitochondria， 329
    7 Mitochondrial Mutations and Disease
    7.1 General Introduction， 346
    7.2 In Cell Culture， 348
    7.3 Molecular Genetics of Human Mitochondrial Diseases， 354
    7.4 Mitochondrial DNA and Aging， 377
    7.5 Mitochondria and Apoptosis， 389
    7.6 Fungal Senescence， 398
    7.7 Cytoplasmic Male Sterility in Plants， 400
    8 Mitochondrial DNA Sequencing and Anthropology
    8.1 Introduction， 418
    8.2 Human Evolution， 419
    8.3 Primate Evolution， 426
    8.4 Human Y Chromosome Variation， 428
    8.5 Forensic Applications， 430
    8.6 Future Challenges， 434
    9 Mitochondria and Pharmacology
    9.1 Introduction， 437
    Index