基因组学、转录组学与代谢组学 = Genomics, trans-criptomics and metabolomics / [edited by] Liu Bin, Wang Keyi. — Beijing : Science Press, 2007. – (58.1481/G335t)

Contents

    目 录<br>    
    1 中文摘要
    基因组学
    7 The impact of genomics on vaccine design
     基因组学对疫苗设计的影响
    15 Applying pharmacogenomics to enhance the use of biomarkers for drug effect and drug safety
     应用药物基因组学强化生物标志物在药物疗效和药物安全性的分子标记中的应用
    20 Genetical genomics in humans and model organisms
     人类及模式生物的遗传基因组学
    25 Moving primate genomics beyond the chimpanzee genome
     从黑猩猩基因组到灵长类基因组学研究<br>    32 Genomics of microRNA
     小分子RNA的基因组学<br>    41 Differences between pair-wise and multi-sequence alignment methods affect vertebrate genome comparisons
     影响脊椎动物基因组比较的成对及多重序列比对方法间的差异<br>    48 Dissecting the mammalian genome-new insights into chromosomal evolution
     解析哺乳动物的基因组——染色体进化的新视点
    53 Many gene and domain families have convergent fates following independent whole-genome duplication events in Arabidopsis，Oryza，Saccharomyces and Tetraodon
     在拟南芥．水稻．酵母与河豚中的独立全基因组复制事件后，多种基因和功能区基因家族具有收敛性<br>    59 Did brain-specific genes evolve faster in humans than in chimpanzees?
     脑特异基因在人类中的进化比在黑猩猩中快吗?
    65 Plant bioinformatics：from genome to phenome
     植物生物信息学：从基因组到表型组
    转录组学与微阵列
    71 Interrogating the transcriptome
     转录组的整合研究
    79 Microarrays-status and prospects
     微阵列的现状和前景<br>    87 Miniaturising the laboratory in emulsion droplets
     乳滴中的微型实验室<br>    95 Surface manipulation of biomolecules for cell microarray applications
     用于细胞微阵列的生物分子表面处理
    102 Small molecule microarrays：from proteins to mammalian cells-are we there yet?
     小分子微阵列：从蛋白质到哺乳动物细胞——离目标还有多远?
    106 Issues in the analysis of oligonucleotide tiling microarrays for transcript mapping
     寡核苷酸嵌合微阵列分析转录本的相关问题<br>    116 Evidence that functional transcription units cover at least half of the human genome
     功能性转录单元至少占人类基因组一半的有关证据
    代谢组学
    120 Metabolomics by numbers：acquiring and understanding global metabolite data
     数字中的代谢物组学：获取和理解整体代谢物数据
    128 Metabolome analysis：the potential of in vivo labeling with stable isotopes for metabolite profiling
     代谢物组学分析：稳定同位素体内标记在代谢物谱中的应用潜力
    134 The next wave in metabolome analysis
     代谢物组学分析的下一个浪潮<br>    137 Can personalized drug therapy be achieved? A closer look at pharmaco-metabonomics
     个体化药物治疗能否实现——近观药物代谢组学<br>    144 Systems analyses characterize integrated functions of biochemical networks
     系统分析鉴定生化网络的整体功能<br>