药理学 = Pharmacology / [edited by] Lin Zhibin. — Beijing : Science Press, 2007. – (63.31/P536h)

Contents

    目 录<br>    
    1 中文摘要
    药理学<br>    8 MAPK-specific tyrosine phosphatases：new targets for drug discovery?
     MAPK特异性酪氨酸磷酸酶：药物发现的新靶点?
    14 Ca2+ signalling and pancreatitis：effects of alcohol， bile and coffee
     Ca2+信号和胰腺炎：酒精、胆汁和咖啡的作用<br>    22 The function of breast cancer resistance protein in epithelial barriers， stem cells and milk secretion of drugs and xenotoxins
     乳腺癌耐药蛋白在上皮屏障、干细胞以及乳汁分泌药物和外毒素中的作用
    29 Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs
     利用P-糖蛋白和BCRP抑制剂改善抗癌药物的口服生物利用度和中枢神经系统渗透性<br>    37 The expression and function of chemokines involved in CNS inflammation
     中枢神经系统炎症中趋化因子的表达和功能<br>    45 The role of the endoplasmic reticulum Ca2+ store in the plasticity of central neurons
     内质网钙池在中枢神经元可塑性中的作用<br>    52 Novel class of pain drugs based on antagonism of NGF
     拮抗神经生长因子的新一类镇痛药
    59 Behavioural pharmacology：40+ years of progress， with a focus on glutamate receptors and cognition
     行为药理学：有关谷氨酸受体与认知40余年研究进展
    67 The quantitative analysis of drug-receptor interactions：a short history
     药物一受体相互作用的定量分析：一段简短的历史
    76 Smooth muscle research：from Edith Bulbring onwards
     始于Edith BUIbring的平滑肌研究
    84 Historical review：ATP as a neurotransmitter
     关于神经递质ATP的历史性回顾<br>    95 Endogenous inverse agonists and constitutive receptor activity in the melanocortin system
     内源性反向激动剂调节黑素细胞皮质激素固有受体活性<br>    99 New light on multidrug binding by an ATP-binding-cassette transporter
     关于ATP结合盒转运蛋白介导的多药结合新见解<br>    108 P2 receptors and cancer
     P2受体与肿瘤<br>    115 Techniques：New pharmacological perspectives for the leptin receptor
     技术：瘦素受体新的药理学前景<br>    123 Targets in ALS：designing multidrug therapies
     设计多药治疗肌萎缩性脊髓侧索硬化症的靶标<br>    130 Angiogenesis：from plants to blood vessels
     血管生成：从药用植物到血管<br>    143 Neurotransmitter transporters：molecular function of important drug targets
     神经递质转运蛋白：重要的药物作用靶标的分子功能<br>    152 Higher-order organization and regulation of adenylyl cyclases
     高级构造与腺苷酸环化酶的调控<br>    158 Transport of glutathione and glutathione conjugates by MRPl
     MRPI介导谷胱苷肽及谷胱苷肽偶联物的转运<br>    167 Analgesic strategies beyond the inhibition of cyclooxygenases
     环氧合酶抑制途径以外的止痛策略<br>    175 Allosteric agonists of 7TM receptors：expanding the pharmacological toolbox
     七次跨膜受体的异构激动剂：更广泛的药理学应用
    182 Chemokine receptors as therapeutic targets in chronic obstructive pulmonary disease
     趋化因子受体作为慢性阻塞性肺部疾病的治疗靶标
    190 How important is protein kinase C in μ-opioid receptor desensitization and morphine tolerance?
     蛋白激酶C在μ-阿片受体脱敏和吗啡耐受中如何发挥重要作用?
    198 Emerging cancer therapeutic opportunities target DNA-repair systems
     靶向DNA修复系统展露出抗肿瘤治疗新机会<br>