Principles and methods of toxicology / edited by A. Wallace Hayes. — 5th ed. — Boca Raton : CRC Press, c2008. – (63.33/H417/5th ed.)

Contents

    Contents
    
    Contributors ix
    Acknowledgments xv
    Foreword to the Third Edition xvii
    Foreword to the Fourth Edition xix
    Foreword to the Fifth Edition xxi
    Preface xxiii
    PART 1 Principles of Toxicology
    1 Harming and Helping through Time: The History of Toxicology 3
    2 The Use of Toxicology in the Regulatory Process 45
    3 Metabolism: A Determinant of Toxicity
    4 Toxicokinetics 179
    5 Physiologically Based Pharmacokinetic and Toxicokinetic Models 231
    6 Toxicopanomics: Applications of Genomics， Proteomics， and Metabonomics in Predictive and Mechanistic Toxicology 293
    7 The Toxicologic Assessment of Pharmaceutical and Biotechnology Products 325
    8 Statistics for Toxicologists 369
    9 Quantitative Extrapolations in Toxicology 453
    10 The Practice of Exposure Assessment 475
    11 Epidemiology for Toxicologists 549
    12 Principles of Pathology for Toxicology Studies 591
    13 The Information Infrastructure of Toxicology 611
    PART 2 Agents
    14 Foodborne Toxicants 633
    15 Solvents and Industrial Hygiene 693
    16 Crop Protection Chemicals: Mechanism of Action and Hazard Profiles 727
    17 Metals 841
    18 Ionizing Radiation 897
    19 Plant and Animal Toxins 983
    PART 3 Methods
    20 The Use of Laboratory Animals in Toxicology Research 1055
    21 Validation and Regulatory Acceptance of New， Revised， and Alternative Toxicological Methods 1103
    22 Acute Toxicity and Eye Irritancy 1131
    23 Genetic Toxicology 1179
    24 Short-Term， Subchronic， and Chronic Toxicology Studies 1223
    25 Principles of Testing for Carcinogenic Activity 1265
    26 Principles of Clinical Pathology for Toxicology Studies 1317
    27 Dermatotoxicology 1359
    28 Inhalation Toxicology 1407
    29 Detection and Evaluation of Chemically Induced Liver Injury 1465
    30 Principles and Methods for Renal Toxicology 1509
    31 Gastrointestinal Toxicology 1541
    32 Principles and Methods of Cardiac Toxicology 1585
    33 Assessment of Male Reproductive Toxicity 1605
    34 Test Methods for Assessing Female Reproductive and Developmental Toxicology 1641
    35 Hormone Assays and Endocrine Function 1713
    36 Immunotoxicology: Effects of and Response to Drugs and Chemicals 1755
    37 Assessment of Behavioral Toxicity 1797
    38 Application of Isolated Organ Perfusion Techniques in Toxicology 1865
    39 Organelles as Tools in Toxicology 1923
    40 Analysis and Characterization of Enzymes and Nucleic Acids 1973
    41 Modem Instrumental Methods for Studying Mechanisms of Toxicology 2041
    42 Methods in Environmental Toxicology 2113
    Glossary 2155
    Index 2193