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Short protocols in neuroscience : systems and behavioral methods / edited by Jacqueline N. Crawley ... [et al.]. — Hoboken, N. J. : Wiley, c2007.—(59.59/S559)

Contents

    CONTENTS
    
    Preface
    Contributors
    1 Neurophysiology
    1.1 Fabrication of Patch Pipets
    1.2 Whole-Cell Voltage Clamp Recording
    1.3 Preparation of Hippocampal Brain Slices
    1.4 Synaptic Plasticity in the Hippocampal Slice Preparation
    1.5 Recording Synaptic Currents and Synaptic Potentials
    1.6 Voltage Clamp Recordings from Xenopus Oocytes
    1.7 Preparation and Maintenance of Organotypic Slice Cultures of CNS Tissue
    1.8 Patch-Pipet Recording in Brain Slices
    1.9 Single-Channel Recording
    1.10 Acute Isolation of Neurons from the Mature Mammalian Central Nervous System
    1.11 Patch-Clamp Recording from Neuronal Dendrites
    2 Neurochemistry/Neuropharmacology
    2.1 Scintillation Proximity Assay
    2.2 Methods for Sample Preparation for Direct Immunoassay Measurement of Analytes in Tissue Homogenates: ELISA Assay of Amyloid β-Peptides
    2.3 Assessment of Cell Viability in Primary Neuronal Cultures
    2.4 Measurement of NO and NO Synthase
    2.5 Measurement of Oxygen Radicals and Lipid Peroxidation in Neural Tissues
    2.6 Overview of Microdialysis
    2.7 Microdialysis in Rodents
    2.8 Mierodialysis in Nonhuman Primates
    2.9 Detection and Quantification of Neurotransmitters in Dialysates
    2.10 Saturation Assays of Radioligand Binding to Receptors and Their Allosteric Modulatory Sites
    2.11 Uptake and Release of Neurotransmitters
    2.12 Measurement of Chloride Movement in Neuronal Preparations
    2.13 Measurement of Cation Movement in Primary Cultures Using Fluorescent Dyes
    2.14 Measurement of Second Messengers in Signal Transduction: cAMP and Inositol Phosphates
    2.15 In Vivo Measurement of Blood-Brain Barrier Permeability
    3 Behavioral Neuroscience
    3.1 Assessment of Developmental Milestones in Rodents
    3.2 Locomotor Behavior
    3.3 Motor Coordination and Balance in Rodents
    3.4 Basic Measures of Food Intake
    3.5 Sexual and Reproductive Behaviors
    3.6 Parental Behaviors in Rats and Mice
    3.7 Application of Experimental Stressors in Laboratory Rodents
    3.8 Rodent Models of Depression: Forced Swimming and Tail Suspension Behavioral Despair Tests in Rats and Mice
    3.9 Rodent Models of Depression: Learned Helplessness Induced in Mice
    3.10 Animal Tests of Anxiety
    3.11 Assessment of Spatial Memory Using the Radial Arm Maze and Morris Water Maze
    3.12 Cued and Contextual Fear Conditioning in Mice
    3.13 Conditioned Flavor Aversions: Assessment of Drug-Induced Suppression of Food Intake
    3.14 Measurement of Startle Response, Prepulse Inhibition, and Habituation
    3.15 Latent Inhibition
    4 Preclinical Models of Neurologic and Psychiatric Disorders
    4.1 Preclinical Models of Parkinson's Disease
    4.2 Rodent Models of Global Cerebral Ischemia
    4.3 Rodent Models of Focal Cerebral Ischemia
    4.4 Inducing Photochemical Cortical Lesions in Rat Brain
    4.5 Protocol Traumatic Brain Injury in the Rat Using the Fluid-Percussion Model
    4.6 Models of Neuropathic Pain in the Rat
    4.7 Dural Inflammation Model of Migraine Pain
    4.8 Animal Models of Painful Diabetic Neuropathy: The STZ Rat Model
    4.9 Models of Nociception: Hot-Plate, Tail-Flick, and Formalin Tests in Rodents
    4.10 Place Preference Test in Rodents
    4.11 Intravenous Self-Administration of Ethanol in Mice
    4.12 Preclinical Models to Evaluate Potential Pharmacotherapeutic Agents in Treating Alcoholism and Studying the Neuropharmacological Bases of Ethanol-Seeking Behaviors in Rats
    4.13 Experimental Autoimmune Encephalomyelitis (EAE)
    4.14 Models of Amyotrophic Lateral Sclerosis
    4.15 Measurement of Panic-Like Responses Following Intravenous Infusion of Sodium Lactate in Panic-Prone Rats
    4.16 Chemoconvulsant Model of Chronic Spontaneous Seizures
    Appendices
    1 Reagents and Solutions
    2 Animal Techniques
    3 Selected Suppliers of Reagents and Equipment
    References