Principles of developmental genetics / Sally A. Moody. — Burlington, MA : Elsevier Inc., Academic Press, c2007.—(58.1484/M817)

Contents

    CONTENTS
    
    PREFACE XI
    I. THE IMPACT OF GENETIC AND GENOMIC TOOLS ON DEVELOPMENTAL BIOLOGY
    1 Untangling the Gordian Knot: Cell Signaling events that Instruct Development 2
    2 Finding Gene Expression Changes Using Microarray Technology 32
    3 Chemical and Functional Genomic Approaches to Study Stem Cell Biology and Regeneration 45
    4 Assessing Neural Stem Cell Properties Using Large-Scale Genomic Analysis 69
    5 Epigenetic Influences on Gene Expression Pathways 92
    6 New Insights into Vertebrate Origins 114
    7 Understanding Human Birth Defects Through Model 129
     Organism Studies
    II. EARLY EMBRYOLOGY， FATE DETERMINATION， AND PATTERNING
    8 Germ Line Determinants and Oogenesis 150
    9 Patterning the Anterior-Posterior Axis During Drosophila Embryogenesis 173
    10 Anterior-Posterior Patterning in Mammals 201
    11 Signaling Cascades， Gradients， and Gene Networks in Dorsal/Ventral Patterning 216
    12 Early Development of Epidermis and Neural Tissue 241
    13 Formation of the Embryonic Mesoderm 258
    14 Endoderm 295
    15 Notch Signaling: A Versatile Tool for the Fine Patterning of Cell Fate in Development 316
    16 Multiple Roles of T-box Genes 341
    III. MORPHOGENETIC AND CELL MOVEMENTS
    17 Gastrulation in Vertebrates 360
    18 Regulation of Tissue Separation in the Amphibian Embryo 392
    19 Role of the Basement Membrane in Cell Migration 404
    20 Epithelial Morphogenesis 424
    21 Branching Morphogenesis of Mammalian Epithelia 448
    22 The Roles of Ephrin-Eph in Morphogenesis 467
    IV. ECTODERMAL ORGANS
    23 Neural Cell Fate Determination 500
    24 Pathfinding and Patterning of Axonal Connections 525
    25 Retinal Development 548
    26 Neural Crest Determination 574
    27 Determination of Preplacodal Ectoderm and Sensory Placodes 590
    28 Molecular Genetics of Tooth Development 615
    29 The Inner Ear 631
    30 Craniofacial Formation and Congenital Defects 656
    V. MESODERMAL ORGANS
    31 Induction of the Cardiac Lineage 680
    32 Heart Patterning and Congenital Defects 698
    33 Blood Vessel Formation 721
    34 Blood Induction and Embryonic Formation 755
    35 Topics in Vertebrate Kidney Formation: A Comparative Perspective 778
    36 Development of the Genital System 805
    37 Diaphragmatic Embryogenesis and Human Congenital Diaphragmatic Defects 829
    38 Formation of Vertebrate Limbs 847
    39 Skeletal Development 866
    VI. ENDODERMAL ORGANS
    40 Patterning the Embryonic Endoderm into Presumptive Organ Domains 908
    41 Developmental Genetics of the Pulmonary System 932
    42 Pancreas Development and Stem Cells 946
    43 Early Liver Development and Hepatic Progenitor Cells 982
    44 Intestinal Stem Cells in Physiologic Regeneration and Disease 1004
    INDEX 1023