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Neurobiology of Alzheimers disease / [edited by] David Dawbarn and Shelley J. Allen. — 2nd ed.— New York ; Oxford : Oxford University Press, 2001.—(64.1984/N494n/2nd ed.) |
Contents
Contents
Colour plate section between pp. 176 and 177
List of contributors ix
List of abbreviations xiii
1 Mzheimer's disease: past， present， and future themes 1
Shelley J. Allen
2 The neuropathology of Mzheimer's disease 33
Margaret M. Esiri3 Molecular genetics of Alzheimer's disease 54
Wilma Wasco
4 The biology and molecular neuropathology of β-amyloid protein 75
D. R. Howlett， D. Allsop， and E. H. Karran
5 The molecular basis of tau protein pathology in
Mzheimer's disease and related neurodegenerative dementias 103
Claude M. Wischik， Franz Theuring， and Charles R. Harrington
6 Apolipoprotein E as a risk factor for Alzheimer's disease 207
Ann M. Saunders
7 The Presenilins 227
Martin Citron
8 Transgenic models of Mzheimer's disease neuropathology 241
Karen Duff
9 Cellular targets of amyloid beta peptide: potential roles in neuronal cell
stress and toxicity 252
Shi Du Yan， Alex Roher， Claudio Soto， Futwan Al-Mohanna， Kate ColIison，<br> Ann Marie Schmidt and David Stern
10 Reflections on Alzheimer's disease as a specific neurotransmitter
disorder 270
Peter Davies
11 Clinical assessment of Mzheimer's disease 280
Suzanne Jeffries and Alistair Burns
12 Molecular and biological markers for diagnosing and monitoring
the progression of Alzheimer's disease 294
Hiroyuki Arai， Makoto Higuchi， Noboyuki Okamura， Yu-ichi Morikawa，<br> Susumu Higuchi， Takeshi Iwatsubo， Eugeen Vanmechelen， Hugo Vanderstichele，<br> John Q. Trojanowski， and Hidetada Sasaki
13 Alzheimer's disease and neuroimaging 312
Nick Fox， Rachael Scahill， Peter Hogh， and Martin Rossor
14 Current pharmacological approaches to treating Alzheimer's disease 338
Rebecca Eastley， Gordon Wilco&， and David Dawbarn
15 Current perspectives， future directions 369
Stephen L Gracon and Mark Emmerling
Appendices 389
AI Amyloid precursor protein 389
AII Presenilin 1 392
AIII Presenilin 2 394
AIV Apolipoprotein E 396
AV Tau 398
AVI α，β and γ-secretases 400
Index 405
