Basic mutagenicity tests : UKEMS recommended procedures : UKEMS Sub-Committee on Guidelines for Mutagenicity Testing : report, part 1. — Rev. — Cambrideg : Cambrideg Universoty Press, 1990.—(58.1428/B311/pt. 1/Rev. ed.)

Contents

            CONTENTS
    
     Steering group vii
     Contributors viii
     List of abbreviations x
    1 Introduction 1
    D. J. Kirkland
    1.1 General 1
    1.2 Special requirements 3
    1.3 Test materials 5
    1.4 Positive controls 7
    1.5 Exogenous metabolic activation 8
    1.6 Presentation of results 10
    1.7 References 11
    2 Bacterial mutation assays 13
    D. G. Gatehouse et al.
    2.1 Introduction 13
    2.2 The test material 19
    2.3 The procedure 21
    2.4 Data processing and presentation 46
    2.5 Discussion 49
    2.6 Conclusions 50
    2.7 References 50
    3 Metaphase chromosome aberration assays in vitro 62
    D. Scott et al.
    3.1 Introduction 62
    3.2 The test material 68
    3.3 The procedure 68
    3.4 Data processing and presentation 75
    3.5 Discussion 82
    3.6 Conclusions 83
    3.7 References 84
     4 Gene mutation assays in cultured mammalian cells 87
     J. Cole et al.
    4.1 Introduction 87
    4.2 The test material 91
    4.3 The procedure 93
    4.4 Data processing and presentation 103
    4.5 Conclusions and recommendations 106
    4.6 References 107
    5.In vivo cytogenetics assays 115
    M. Richold et al.
    5.1 Introduction 115
    5.2 Experimental design 119
    5.3 The procedure 125
    5.4 Summary and conclusions 137
    5.5 References 137
    Index 143