International review of neurobiology. v. 77, The pharmacology of neurogenesis and neuroenhancement / edited by Donard S. Dwyer. — Amsterdam : Elsevier, c2007. – (59.58/P526/v.77) |
Contents
CONTENTS
Regenerating the Brain
I. Introduction
II. Neurodegenerative Diseases: Therapeutic Targets for Neurogenesis
III. Building Brains: Evolution and Development
IV. Endogenous and Exogenous Sources of New Neurons
V. Endogenous Adult Neurogenesis
VI. Injury-Induced Neurogenesis
VII. Neurogenesis in Stroke
VIII. Neurogenesis in AD
IX. Neurogenesis in HD
X. Neurogenesis in PD
XI. Neurogenesis in Motor Neuron Disease
XII. Convergent and Divergent Features of Injury-Induced Neurogenesis
XIII. Unanswered Questions
References
Serotonin and Brain: Evolution, Neuroplasticity, and Homeostasis
I. Introduction
II. Evolution: From Unicellular to Humans
III. Holistic Brain Function Starts at Development
IV. Homeostasis of Brain
V. Clinical Implications of Loss of Homeostasis
References
Therapeutic Approaches to Promoting Axonal Regeneration in the Adult Mammalian Spinal Cord
I. Introduction
II. Growth-Inhibiting Properties of the Glial Scar
III. Inhibition of Axonal Regeneration by CNS Myelin
IV. Cell-Based Strategies to Promote Regeneration
V. Future Directions
References
Evidence For Neuroprotective Effects of Antipsychotic Drugs: Implications for the Pathophysiology and Treatment of Schizophrenia
I. Introduction
II. Altered Levels of NTs and Their Receptors by Antipsychotic Drugs
III. The Regulation of Neurogenesis by Antipsychotic Drugs
IV. Neuroprotective Effects of Antipsychotic Drugs
References
Neurogenesis and Neuroenhancement in the Pathophysiology and Treatment of Bipolar Disorder
I. Introduction
II. Clinical Evidence for a Role of Neuroplasticity in BPD
III. Preclinical In Vivo and In Vitro Studies
IV. Conclusions
References
Neuroreplacement, Growth Factor, and Small Molecule Neurotrophic Approaches for Treating Parkinson's Disease
I. Introduction
II. Etiology of PD
III. Current Treatment for PD
IV. Rodent Models of PD Used to Evaluate Putative Neuroprotective Therapies
V. Approaches to Brain Repair in PD
VI. Summary and Conclusions
References
Using Caenorhabditis elegans Models of Neurodegenerative Disease to Identify Neuroprotective Strategies
I. Introduction
II. C. elegans Models of Neurodegenerative Disorders
III. Identifying Candidate Modifier Genes of Neurodegeneration
IV. Molecular Inhibitors of Neurodegeneration
V. Neuroprotective Strategies
VI. Utility of HTS for Drugs in Worms
VII. Conclusions
References
Neuroprotection and Enhancement of Neurite Outgrowth with Small Molecular Weight Compounds from Screens of Chemical Libraries
I. Introduction
II. Brain Deficit Disorders: The Challenges
III. Treatment Objectives
IV. Application to Neurodevelopmental Disorders: Schizophrenia ..
V. Screening and Identification of Novel Compounds for Drug Discovery
VI. Neurodevelopmental Disorders and Neurodegenerative Diseases
VII. Future Directions
References
INDEX
CONTENTS OF RECENT VOLUMES