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International review of neurobiology. v. 77, The pharmacology of neurogenesis and neuroenhancement / edited by Donard S. Dwyer. — Amsterdam : Elsevier, c2007. – (59.58/P526/v.77)

Contents

    CONTENTS
    
    Regenerating the Brain
    I. Introduction
    II. Neurodegenerative Diseases: Therapeutic Targets for Neurogenesis
    III. Building Brains: Evolution and Development
    IV. Endogenous and Exogenous Sources of New Neurons
    V. Endogenous Adult Neurogenesis
    VI. Injury-Induced Neurogenesis
    VII. Neurogenesis in Stroke
    VIII. Neurogenesis in AD
    IX. Neurogenesis in HD
    X. Neurogenesis in PD
    XI. Neurogenesis in Motor Neuron Disease
    XII. Convergent and Divergent Features of Injury-Induced Neurogenesis
    XIII. Unanswered Questions
    References
    Serotonin and Brain: Evolution, Neuroplasticity, and Homeostasis
    I. Introduction
    II. Evolution: From Unicellular to Humans
    III. Holistic Brain Function Starts at Development
    IV. Homeostasis of Brain
    V. Clinical Implications of Loss of Homeostasis
    References
    Therapeutic Approaches to Promoting Axonal Regeneration in the Adult Mammalian Spinal Cord
    I. Introduction
    II. Growth-Inhibiting Properties of the Glial Scar
    III. Inhibition of Axonal Regeneration by CNS Myelin
    IV. Cell-Based Strategies to Promote Regeneration
    V. Future Directions
    References
    Evidence For Neuroprotective Effects of Antipsychotic Drugs: Implications for the Pathophysiology and Treatment of Schizophrenia
    I. Introduction
    II. Altered Levels of NTs and Their Receptors by Antipsychotic Drugs
    III. The Regulation of Neurogenesis by Antipsychotic Drugs
    IV. Neuroprotective Effects of Antipsychotic Drugs
    References
    Neurogenesis and Neuroenhancement in the Pathophysiology and Treatment of Bipolar Disorder
    I. Introduction
    II. Clinical Evidence for a Role of Neuroplasticity in BPD
    III. Preclinical In Vivo and In Vitro Studies
    IV. Conclusions
    References
    Neuroreplacement, Growth Factor, and Small Molecule Neurotrophic Approaches for Treating Parkinson's Disease
    I. Introduction
    II. Etiology of PD
    III. Current Treatment for PD
    IV. Rodent Models of PD Used to Evaluate Putative Neuroprotective Therapies
    V. Approaches to Brain Repair in PD
    VI. Summary and Conclusions
    References
    Using Caenorhabditis elegans Models of Neurodegenerative Disease to Identify Neuroprotective Strategies
    I. Introduction
    II. C. elegans Models of Neurodegenerative Disorders
    III. Identifying Candidate Modifier Genes of Neurodegeneration
    IV. Molecular Inhibitors of Neurodegeneration
    V. Neuroprotective Strategies
    VI. Utility of HTS for Drugs in Worms
    VII. Conclusions
    References
    Neuroprotection and Enhancement of Neurite Outgrowth with Small Molecular Weight Compounds from Screens of Chemical Libraries
    I. Introduction
    II. Brain Deficit Disorders: The Challenges
    III. Treatment Objectives
    IV. Application to Neurodevelopmental Disorders: Schizophrenia ..
    V. Screening and Identification of Novel Compounds for Drug Discovery
    VI. Neurodevelopmental Disorders and Neurodegenerative Diseases
    VII. Future Directions
    References
    INDEX
    CONTENTS OF RECENT VOLUMES