Imaging in drug discovery and early clinical trials / edited by Markus Rudin. — Basel ;Boston : Birkhauser Verlag, 2005. – (63.32/F744/v.62)

Contents

    Contents
    
    The drug discovery process 1
    Imaging modalities: principles and information content 15
    Magnetic resonance and fluorescence based molecular imaging technologies 83
    Studying molecular and cellular processes in the intact organism 117
    Disease phenotyping: structural and functional readouts 151
    Evaluation of drug candidates: efficacy readouts during lead optimization 185
    Risk identification and management: MRI as a research tool in toxicology studies of new chemical entities 257
    Pharmacokinetic studies with PET 279
    Imaging biomarkers predictive of disease/therapy outcome: ischemic stroke and drug development 319
    Clinical drug evaluation using imaging readouts: regulatory perspectives 357
    Index 385