Advances in enzyme regulation. v. 46 / edited by George Weber, Catherine E. Forrest Weber, Lucio Cocco. — Oxford : Elsevier Ltd., c2006. – (59.5177/A244/v.46)

Contents

        Contents
    
    SESSION I
    NUCLEAR REGULATION
    Signal Transduction within the Nucleus: Revisiting Phosphoinositide Inositide Specific Phospholipase C 2
    Analysis of Two Diacylglycerol Kinase Activities in Mixed Micelles 12
    SESSION II
    REGULATION OF METABOLIC PATHWAYS
    Metabolic Regulation and Chemotherapy 26
    Laminopathies: A Chromatic Affair 33
    SESSION III
    REGULATION OF CARBOHYDRATE ENZYMES
    Localization and Regulation of Muscle Fructose-1， 6-bisphosphatase， the Key Enzyme of Glyconeogenesis 51
    Roles for Fructose-2， 6-Bisphosphate in the Control of Fuel Metabolism: Beyond its Allosteric Effects on Glycolytic and Gluconeogenic Enzymes 72
    SESSION IV
    REGULATION IN NEOPLASIA
    A Role for Mitotic Recombination in Leukemogenesis 90
    Characterization of the Hemopoietic Defect in Early Stages of the Myelodysplastic Syndromes 98
    Nrf2-Keapl Regulation of Cellular Defense Mechanisms Against Electrophiles and Reactive Oxygen Species 113
    SESSION V
    PHOSPHATE AND REGULATION
    SHIP1/2 Interaction with Tyrosine Phosphorylated Peptides Mimicking an Immunoreceptor Signaling Motif 142
    A Novel Function of Phosphate-Mediated Intracellular Signal Transduction Pathways 154
    SESSION VI
    REGULATION IN HUMAN CANCER CELLS
    Caveoln-I Inhibits Anoikis and Promotes Survival Signaling in Cancer Cells 163
    Modulation of Cancer Pathways by Inhibitors of Guanylate Metabolism 176
    SESSION VII
    NEURO-REGULATION
    Diacylglycerol Kinase and Animal Models: the Pathophysiological Roles in the Brain and Heart 192
    Protein Phosphatase Regulation by PRIP， a PLC-related Catalytically Inactive Protein: Implications in the Phospho-Modulation of the GABAA Receptor 203
    SESSION VIII
    CONTROL OF KEY ENZYMES AND NEOPLASIA
    Regulation of DNA Methyltransferase I 224
    Enzymic Properties and Analysis of p53R2 Subunit of Human Ribonucleotide Reductase 235
    SESSION IX
    PI3 K AND REGULATION
    Roles of the Raf/MEK/ERK and PI3K/PTEN/AKT Pathways in Malignant Transformation and Drug Resistance 249
    Activation of Phosphatidylinositol 3-Kinase C2J3 in the Nuclear Matrix during Compensatory Liver Growth 280
    SESSION X
    PHOSPHORYLATION AND LIPID TRAFFICKING
    PIKE Tyrosine Phosphorylation Regulates its Apoptotic Cleavage During Programmed Cell Death 289
    Phosphatidylinositol Transfer Proteins: From Closed Transport to Open for Exchange 301
    SESSION XI
    SPECIAL SYMPOSIUM LECTURE: R. F. IRVINE
    The Regulation and Function of Inositol 1，4，5-trisphosphate 3-Kinases 314