Developmental biology of neoplastic growth / edited by Alvaro Macieira-Coelho. — Berlin : Springer, c2005. –(58.1/P964m/V.40)

Contents

        Contents
    
    The Hedgehog Signaling Pathway in Cancer 1
    1 Introduction 1
    2 The Hedgehog Signaling Pathway 1
    3 Hh Signaling in Tumor Formation and Growth 6
    4 Small-Molecule Hh Signaling Antagonists -a Therapeutic Opportunity? 15
    5 Future Prospects 17
    References 18
    Rho GTPases and Cancer 29
    1 Introduction 29
    2 Rho Proteins and Tumorigenesis 32
    3 Elevated Rho GTPase Signaling in Tumorigenesis 32
    4 Upstream Regulation of Rho GTPases 34
    5 Downstream Signaling Pathways 36
    6 Cross Talk Between Racl And Wnt Signaling Pathways 43
    7 Rho GTPases as Therapeutic Targets 44
    8 Future Directions 46
    References 47
    Developmental Biology of Fibroblasts and Neoplastic Disease 55
    1 Introduction 55
    2 What Are Fibroblasts? 55
    3 Evidence of Fibroblast Diversity in a Two-Dimensional (2-D) Culture Model 60
    4 Fibroblasts from Non-Tumoral and Tumoral Breast Tissue 67
    5 What Really Are Fibroblasts? 69
    6 Attempts to Study Fibroblast-Epithelial Cell Interaction in a Novel Dimension 72
    References 74
    The Extracellular Matrix During Normal Development and Neoplastic Growth 79
    1 Introduction 79
    2 Extracellular Matrix During Development 80
    3 Laminin Isoforms in Tumor Progression 84
    4 Proteolytic Degradation of Matrix Components， Generation of Biologically Active Peptides: Matricryptins. 88
    5 Tumor Growth and Matrix Biosynthesis 90
    6 Role of Receptor Signaling in Cell Matrix Interaction During Normal Development and Tumor Growth 91
    7 Glycosaminoglycans and Proteoglycans in Normal Development and Tumor Progression 95
    8 Discussion and Conclusions 97
    References 99
    Wilms' Tumor: Starting Off the Kidney All Over Again? 107
    1 Wilms' Tumor and the WT1 Gene 107
    2 A Role for Other Genes and Chromosomal Regions in Wilms' Tumor 110
    3 Setting the Stage - Normal Kidney Development 111
    4 A Case for Disrupted Development 114
    5 Lessons to he Learned 120
    References 126
    Testicular Teratomas: Back to Pluripotent Stem Cells 133
    1 Introduction 133
    2 Cellular Basis of Teratoma Formation 135
    3 EG Cells 137
    4 Genetic and Molecular Bases of Teratoma Formation 141
    5 Perspectives: Implications for Stem Cell Biology 145
    References 146
    Tumor Suppressors APC and VHL: Gatekeepers of the Intestine and Kidney 151
    1 Introduction and Background 151
    2 Colorectal Canter: Current Understanding of the: Molecular Mechanism 152
    3 Clear Cell Renal Carcinoma: Current Understanding of the Molecular Mechanism 162
    4 Discussion 170
    References 172
    Hormonal and Stromal Regulation of Normal and Neoplastic Prostatic Growth 183
    1 Introduction 183
    2 Prostatic Growth and Development 184
    3 Prostate Cancer 195
    4 Conclusion 207
    References 208
    Neoplastic Growth Through the Developmental Stages of the Organism 217
    1 Developmentally and Nondevelopmentally Related Events in the Natural History of Cancers 217
    2 Putative Mechanisms of Developmentally Related Events in the Natural History of Cancers 225
    References 240
    Subject Index 251