Contents 1.Architecture and dynamics of mammalian genomes 1 2.Functional organization of chromosomes in the interphase cell nucleus 19 3.Organization and dynamics of the cell nugleus for DNA replication 37 4.How one nucleus makes two nuclei: the nucleus in mitosis 52 5.Epigenetic features that influence nuclear function in higher eukaryotes 67 6.The Organization of transcription in the nucleus of mammalian cells 95 7.PRE-mRNA processing in the nuclear landscape 106 8.The nucleolus: an essential nuclear domain 120 9.Promyelocytic leukemia nuclear bodies: cellular function and disease association 136 10.The cajal body: a nuclear gathering place 159 11The interchromosomal domain compartment: an active space within the nucleus 172 12.Subnuclear pathology 184 13.Nuclear components and tumor markers 204 14.Visualization and quantification of dynamic processes in live cell nuclei 225 15.Fluorescence resonance energy transfer: analysis of protein-protein interactions in and around the nucleus 239 16.Fluorescence correlation spectroscopy: Perspectives for in vivo characterization of single-molecule dynamics 248 17.Multiphoton multicolor fluorescence in situ hybridization and naoprocessing of chromosomes with near-infrared femtosecond laser pulses 268 18.Damage in human cell nuclei in toxicology, nutrition, and cancer: visualization by comet assay and comet-fish 281 |