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The laboratory mouse / edited by Hans H. Hedrich and Gillian Bullock. -- (The Handbook of experimental animals). -- Elsevier, 2004. -- (59.191938/L123)

Contents

Contents:

1. Origin of the Laboratory Mouse and Related Subspecies  3

2. Historical Foundations  15

3. Strains, Stocks, and Mutant Mice  25

4. Mouse Genomics  47

5. Generation of Mouse Mutants by Sequence Information Driven and Random Mutagenesis  85

6. The Mouse as an Animal Model for Human Diseases  97

7. The Mouse in Preclinical Safety Studies  111

8. Gross Anatomy  117

9. Normative Histology  of Organs  133

10. Imaging  167

11. Introduction to Early Mouse Development  175

12. Skin and Adnexa of the Laboratory Mouse  195

13. the Cardiovascular System  207

14. Respiratory Tract  225

15. gastrointestinal System and Metabolism  245

16. Inbred Mouse Models for autoimmune Disease  261

17. Hematology of the Mouse  271

18. The social Behaviour of Mice and its Sensory Control  287

19. Neuroendocrine-Immune Network in Stress  301

20. Circadian Rhythms of the Mouse  311

21. Gerontology  327

22. Diversity of Spontaneous Neoplasms in Commonly Used Inbred Strains and Stocks of Laboratory Mice  345

23. Viral Infections  357

24. Housing and Maintenasce  395

25. Gnotobiology and Breeding Techniques  409

26. Assisted Reproduction and Cryopreservation  435

27. Health Monitoring  449

28. Nutrition of Laboratory Mice  463

29. Legal Regulations for the Protection of Animals Used for Scientific Experiments  483

30. Necropsy Methods  495

31. Handling and Restraint  517

32. Routes of Administration  527

33. Collection of Body Fluids  543

34. Anesthesia, Analgesia and Euthanasia  555

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