autoimmunity : methods and protpcpls / edited by Andras Perl. -- (Methods in molecular medicine ; 102). -- 63.17/A939a

Contents:

1. Pathogenesis and Spectrum of Autoimmunity  1

2. Mapping the Systemic Lupus Erythematosus Susceptibility Genes  11

3. T-Cell Signaling Abnormalities in Human systemic Lupus Erythematosus  31

4. TCR ζ -Chain Abnormalities in Human Systemic Lupus Erythematosus  49

5. Protein Kinase A and Signal Transduction in T Lymphocytes: biochemical and Molecular Methods  73

6. Apoptosis and Mitochondrial Dysfunction in Lymphocytes of Patients With Systmeic Lupus Erythematosus  87

7. Methods for Inducing Apoptosis  115

8. Measurement of Cytokines in Autoimmune Disease  129

9. Evaluation of Autoimmunity to Transaldolase in Multiple Sclerosis  155

10. Animal Models for Autoimmune Myocarditis and Autoimmune Thyroiditis  175

11. Animal Models of Insulin-Dependent Diabetes  195

12. Generation, Maintenance, and Adoptive Transfer of Diabetogenic T-Cell Lines/Clones From the Nonobese Diabetic Mouse  213

13. Experimental Use of Murine Lupus Models  227

14. The Anti-DNA Knock-In Model of systemic Autoimmunity Induced by the Chronic Graft-vs-Host Reaction  273

15. Murine Models of Lupus Induced by Hypomethylated T Cells  285

16. The Mouse Model of Collagen-Induced Arthritis  295

17. Proteoglycan Aggrecan-Induced Arthritis: A Murine Autoimmune Model of Rheumatoid Arthritis  313

18. Mouse Models of Multiple Sclerosis: Experimental Autoimmune Encephalomyelitis and Theiler's Virus-Induced Demyelinating Disease  339

19. Experimental Autoimmune Encephalomyelitis  363

20. Animal Models of Scleroderma  377

21. Rodent Models of Experimental Autoimmune Uveitis  395

22. Autoimmune Depigmentation following Sensitization to Melanoma Antigens  321