Protein crystallography in drug discovery / edited by R. E. Babine and S. S. Abdel-Mrguid. -- Wiley-VCH., 2004. -- 63.32/P967

Contents

Contents:

1. Molecular Recognition of Nuclear Hormone Receptor-Ligand Complexes  1

2. Kinases  47

3. The Proteasome as a Drug Target  83

4. Antibiotics and the Ribosome  99

5. Structure-Based Design of Cathepsin K Inhibitors  127

6. Structure-Basedn Design of Potent and Selective Cdk4 Inhibitors  147

7. Crystallization and Analysis of Serine Proteases with Ecotin  171

8. X-ray Crystallography in the Development of Orthogonal Ligand-Receptor Pairs  187

9. Engineering Proteins to Promote Crystallization  209

10. High-throughput Crystallography  217

11. Micro-Crystallization  235