Modulating aging and longevity / edited by Suresh I.S. Rattan. -- (Biology of aging and its modulation ; v.5). -- Kluwer Academic Pub., 2003

Contents

1. Modulating aging, longevity determination and the diseases of old age  1

2. The modulation of lifespan by natural selection  17

3. Early--life factors modulating lifespan  27

4. Selective breeding for slower aging and greater lifespan  51

5. Slowing down cellular aging in vitro  65

6. Escaping cellular senescence in vitro  85

7. Stress, cells and tissue aging  101

8. Hormesis in aging and longevity  127

9. Therapeutic interventions for age-related muscle wasting  139

10. Slowing down aging in the skin  167

11. Antioxidants as modulators  183

12. Mitochondrial interventions in aging and longevity  205

13. Hormonal interventions of aging and longevity  219

14. Effect of melatonin on longvity  239

15. Nutritional modulation of aging: effect of caloric restriction  261

16. Small peptide-associated modulation of aging and longvity  279

17. Gene expression profiling to study aging and its modulation  303